The Breakthroughs Powering Culture-Free Diagnostics.
SPLENDID™ isolates and characterizes pathogens directly from whole blood, providing results without needing blood culture.
The SPLENDID™ platform is built around the capability of capturing and characterizing rare cells directly from clinical specimens.
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Microfluidic Pathogen Capture
Capture every bacterial and fungal pathogen and eliminate host cells.
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Super-Resolution Microscopy
Label-free imaging and monitoring of live, whole pathogens.
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AI-Powered Image Analysis
Identify pathogens using algorithms trained with proprietary image libraries.
The Holy Grail of Diagnostics.
Capture 1-100 pathogens for every billion human cells in a standard 10 mL blood sample and provide clinically actionable results in minutes.
» BLASTID is transforming diagnostics
See what’s hiding in a 10 mL blood sample
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~50 Billion
Red Blood Cells
(6–8 µm)
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1-100
Pathogens
(1–2 µm)
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![Illustration of a human white blood cell with its nucleus visible.]()
50-100 M
White Blood Cells
(12–17 µm)
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~3 Billion
Platelets
(2–4 µm)
PATHOGEN ENRICHMENT
Microfluidic Capture.
SPLENDID's pathogen enrichment technology for single-cell analysis was co-developed with researchers from the Paulsson Lab at Harvard Medical School.
Ultra-rapid capture of live pathogens from 5-10 mL of blood with >99.99% efficiency. The gentle process keeps all bacteria and fungal cells viable for downstream species-level ID and phenotypic AST.
Microfluidic capture of bacteria occurs in minutes via the SPLENDID™ Platform
LIVE IMAGING
Super-Resolution Microscopy.
Our label-free, single-cell optical identification system uses Differential Phase Microscopy (DPC) to classify and identify pathogens, enabling ultra-rapid and cost-effective detection even in polymicrobial infections.
SPECIES ID & AST
AI-Powered Image Analysis.
Trained on hundreds of thousands of pathogen images, SPLENDID™’s AI-powered image algorithms analyze real-time morphological changes and growth patterns to determine ID & AST profiles for personalized patient treatments.
The platform capitalizes on direct observation of live cells growing, dividing, and responding to antibiotics.
See antibiotic effects on susceptible E. coli (top) and uninhibited growth of S. aureus clusters (bottom) on chip.
